In vivo tissues are soft, elastic and mechanically textured. Living tissues rigidity properties present microscale variations that can play a crucial role in cell response (in a same tissue, rigidity varies from Pa/mm to kPa/μm).. Relying on unique patented technologies and know-how derived from the microelectronic field, the mechanical properties of Mecachips® matrices can be finely tuned up to the μm scale to replicate such variations.

DESCRIPTION

MecaChips® soft and micropatterned culture plates are new and physiological solutions for in vitro cell culture, that mimic the mechanical cell environment, all while giving you the chance to control it at the micrometer scale.

APPLICATIONS

AREAS

Basic research, stem cells, oncology, neurology, cardiology.

TOOLS

Adhesion, cell shape standardization, cell confinement, cell migration.

CHARACTERISTICS

BENEFITS

• Robust & reliable

• Ready & easy to use

• Scalable to screening workflow (no topography)

• No biological risk (synthetic matrix)

• Glass bottom: ideal for microscopy

• Stiffness and coating are decoupled

STORAGE

• Temperature: +4°C

• Shelf life: 3 months

SHAPES*

• Subcellular to cellular scale (1 - 100 μm): geometrics patterns (dots, triangles, stripes)

• Tissue scale (Pa/mm to kPa/μm): steps, gradients

*Custom patterns upon request

CUSTOMIZATION

CHOOSE YOUR STIFFNESS

Stiffness according to the organ of interest:

• 1 kPa (breast)

• 3 kPa (liver)

• 3,5 kPa (pancreas)

• 4 kPa (lung)

• 5 kPa (artery | skin)

• 6 kPa (brain)

• 8 kPa (spleen)

• 9 kPa (kidney)

• 10 kPa (heart)

• >25 kPa (cartilage)

CHOOSE YOUR COATING

Culture dishes and plates are pre-coated with ECM protein or synthetic amino acid.

Culture dedicated surface chemistry:

• Vitronectin (human; recombinant truncated)

• Fibronectin (human; plasma)

• Collagen I (rat; tail)

• Laminin (mouse; EHC sarcoma)

• Poly-Ornithine | Laminin

• Poly-Ornithine

UNIQUE FORMAT

• PD35

PRODUCT SHEET

Download product sheet here.