"Our group is interested in the mechanisms of adaptation of lung cells to metabolic changes in their microenvironment. The latter is complex and multifactorial. Therefore, the study of its impact on cells requires its in-vitro modeling in order to better characterize the underlying mechanisms and their pharmacological targeting. However, the impact of classic plastic supports, which are extremely rigid, strongly modify the basal metabolic activities of the cells, leading to experimental biases and therefore an erroneous reflection of the physiopathology. Our collaboration with Cell&Soft allows us to revisit these mechanisms by limiting the drift related to plastic as much as possible and, in fact, to develop much more relevant models. More generally, we firmly believe that taking tissue mechanics into account in in-vitro approaches will make it possible to better represent the environment of the cell and therefore lead to the identification of new molecules of interest for patients."

DR CHAVEROUX, Research fellow CNRS , Cancer Research Center of Lyon (CRCL)