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OUR PRODUCTS

Cell&Soft provides uniformly soft or rigidity textured cell culture plates, with an

adhesive coating.
 

The culture plates offer mechanical features as close as possible to those found in vivo in animal or human tissues.

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Uniform Rigidity

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CHOOSE YOUR RIGIDITY

1

Choose between 11 rigidities available, according to your organ of interest from brain to cartilage.

CHOOSE YOUR FORMAT

CHOOSE YOUR COATING

2

3

Choose between 6 coatings available. The surface density of the coating is independent of the rigidity.

  • Available in standard format*

  • Compatible with standard analysis

  • Scalable to screening workflow

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PROTEINOGENIC AMINO ACID

Collagen I (rat tail)

Vitronectin (human truncated recombinant)

Fibronectin (human plasma)

P6

P12

BP35

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Laminin (mouse EHS sarcoma)​

NON-PROTEINOGENIC AMINO ACID

Poly-ornithine

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P24

P48

P96

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*p384 upon request

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TexturedRigidity

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Zoom on the local stiffness of a human pituitary gland (hypohysis) tissue, measured by force indentation atomic force microscopy. Adapted from 2.

Visit our on line catalogue and contact us for more information.

References

  1. M. Moussus, C. der Loughian, D. Fuard, M. Courcon, D. Gulino-Debrac, H. Delanoe-Ayari, and A. Nicolas . Intracellular stresses in patterned cell assemblies. Soft Matter, 10 :2414–2423, 2014.

  2. M. Moussus, C. der Loughian, D. Fuard, M. Courçon, D. Gulino Debrac, H. Delanoë-Ayari, and A. Nicolas. Reply to the ’comment on "intracellular stresses in patterned cell assemblies"’ by D. Tambe et al., Soft Matter, 2014, 10, 7681. Soft Matter, 10 :7683–7684, 2014.

  3. N. Bouchonville, M. Meyer, C. Gaude, E. Gay, D. Ratel, and A. Nicolas. AFM mapping of the elastic properties of brain tissue reveals kPa/µm gradients of rigidity. Soft Matter, 12 :6232–6239, 2016.

  4. A. Nicolas. Cell adhesion mechanosensitivity, an active biological process. Comment on ”cellular mechanosensing of the biophysical microenvironment : A review of the mathematical models of biophysical regulation of cell responses” by Bo Cheng et al. Phys. Life Rev., 22-23 :123–126, 2017.

  5. N. Bouchonville and A. Nicolas . Quantification of the elastic properties of soft and sticky materials using AFM. In N. C. Santos and F. A. Carvalho, editors, Meth. Mol. Biol., Atomic Force Microscopy : Methods and Protocols, 281–290, 2019.

  6. C. Tomba, C. Migdal, D. Fuard, C. Villard, and A. Nicolas. Glial cell mechanosensitivity is reversed by adhesion cues. BioRxiv, 865303, 2019.

  7. S. Palva, P. Joanne, C. Migdal, E. Lopez-Soler, Y. Hovhannisyan, A. Nicolas, and O. Agbulut . Polyacrylamide hydrogels with rigidity-independent surface chemistry show limited long-term maintenance of pluripotency of human induced pluripotent stem cells on soft substrate. ACS Biomat. Sci. Eng., 6 :340-351, 2020.