OUR PRODUCTS

Uniform rigidity : The MecachipsTM

Cell&Soft provides uniformly soft or rigidity-textured cell culture plates, with an adhesive coating.
The culture plates offer mechanical features as close as possible to those found in vivo in animal or human tissues.

CHOOSE YOUR ORGAN OF INTEREST

Choose between 11 rigidities available, according to your
organ of interest from brain to cartilage :

CHOOSE YOUR COATING

The surface density of the coating is
independent of the rigidity :

PROTEIN

Vitronectin (human truncated recombinant)

Laminin (mouse EHS sarcoma)​

Collagen I (rat tail)

Fibronectin (human plasma)

Poly-ornithine

CHOOSE YOUR FORMAT

Available in standard format*
Compatible with standard analysis
Scalable to screening workflow

BP35

P24

P6

P48

P12

P96

*p384 upon request

Textured rigidity : The µpattern MecachipsTM

Zoom on the local stiffness of a human pituitary gland (hypohysis) tissue,

measured by force indentation atomic force microscopy. Adapted from 2 :

Visit our on line catalogue and contact us for more information.

References

  1. M. Moussus, C. der Loughian, D. Fuard, M. Courcon, D. Gulino-Debrac, H. Delanoe-Ayari, and A. Nicolas . Intracellular stresses in patterned cell assemblies. Soft Matter, 10 :2414–2423, 2014.

  2. M. Moussus, C. der Loughian, D. Fuard, M. Courçon, D. Gulino Debrac, H. Delanoë-Ayari, and A. Nicolas. Reply to the ’comment on "intracellular stresses in patterned cell assemblies"’ by D. Tambe et al., Soft Matter, 2014, 10, 7681. Soft Matter, 10 :7683–7684, 2014.

  3. N. Bouchonville, M. Meyer, C. Gaude, E. Gay, D. Ratel, and A. Nicolas. AFM mapping of the elastic properties of brain tissue reveals kPa/µm gradients of rigidity. Soft Matter, 12 :6232–6239, 2016.

  4. A. Nicolas. Cell adhesion mechanosensitivity, an active biological process. Comment on ”cellular mechanosensing of the biophysical microenvironment : A review of the mathematical models of biophysical regulation of cell responses” by Bo Cheng et al. Phys. Life Rev., 22-23 :123–126, 2017.

  5. N. Bouchonville and A. Nicolas . Quantification of the elastic properties of soft and sticky materials using AFM. In N. C. Santos and F. A. Carvalho, editors, Meth. Mol. Biol., Atomic Force Microscopy : Methods and Protocols, 281–290, 2019.

  6. C. Tomba, C. Migdal, D. Fuard, C. Villard, and A. Nicolas. Glial cell mechanosensitivity is reversed by adhesion cues. BioRxiv, 865303, 2019.

  7. S. Palva, P. Joanne, C. Migdal, E. Lopez-Soler, Y. Hovhannisyan, A. Nicolas, and O. Agbulut . Polyacrylamide hydrogels with rigidity-independent surface chemistry show limited long-term maintenance of pluripotency of human induced pluripotent stem cells on soft substrate. ACS Biomat. Sci. Eng., 6 :340-351, 2020.

Menu
Adresse & Contact

Cell&Soft SAS

Tél : +33 (0)4 38 78 48 10

contact@cellandsoft.com

c/o CEA-LTM-CNRS

Bâtiment 44

17 av des Martyrs,

38054 Grenoble cedex 9, France

  • LinkedIn Social Icône

© 2020 par Cell&Soft SAS.