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MecaChips®

 

SOFT CULTURE PLATES FOR PLEASED CELLS

by Cell&Soft

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Mechano-mimetic cell culture: uniform rigidity​

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Hypophysis

Zoom on the local stiffness of a human pituitary gland (hypophysis) tissue, measured by force indentation atomic force microscopy. Adapted from 2.

DESCRIPTION

Cell&Soft culture plates offer mechanical features as close as possible to those found in vivo in animal or human tissues. Mecachips® soft and flat matrices are new and physiological solutions for in vitro cell culture. They mimic the soft mechanical features of all human or animal tissues, thus preserving the cells in vivo characteristics.

APPLICATIONS

AREAS

Basic research, stem cells, oncology, neurology, cardiology, compatible with HCS/HTS platforms.

TOOLS

Cell biology, molecular biology, biochemistry.

CHARACTERISTICS

BENEFITS

  • Robust & reliable

  • Ready & easy to use

  • Scalable to screening workflow (no topography)

  • No biological risk (synthetic matrix)

  • Glass bottom: ideal for microscopy

  • Stiffness and coating are decoupled

  • Compatible with standard analysis

STORAGE

  • Temperature: +4°C

  • Shelf life: 3 months

CUSTOMIZATION

CHOOSE YOUR STIFFNESS

Stiffness according to the organ of interest:

  • 1 kPa (breast)

  • 3 kPa (liver)

  • 3,5 kPa (pancreas)

  • 4 kPa (lung)

  • 5 kPa (artery | skin)

  • 6 kPa (brain)

  • 8 kPa (spleen)

  • 9 kPa (kidney)

  • 10 kPa (heart)

  • >25 kPa (cartilage)

CHOOSE YOUR COATING

Culture dishes and plates are pre-coated with ECM protein or synthetic amino acid.

Culture dedicated surface chemistry:

  • Vitronectin (human; recombinant truncated)

  • Fibronectin (human; plasma)

  • Collagen I (rat; tail)

  • Laminin (mouse; EHC sarcoma)

  • Poly-Ornithine | Laminin

  • Poly-Ornithine

CHOOSE YOUR FORMAT

Standards formats*

  • PD35

  • P6

  • P12

  • P24

  • P48

  • P96

*P384 upon request

In vivo, cells lay in soft tissues with distinct physical properties. Rigidity plays a major role in a myriad of cellular mechanisms, such as carcinogenesis and metastasis formation, as well as stem cells differentiation and drug effectiveness. To be representative, in vitro cell devices should selectively provide culture conditions as close as possible to the mechanical microenvironment of targeted tissues. 

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