µpattern MecaChips®

 

CONTROL YOUR MECHANICAL CELL ENVIRONMENT

AT THE MICROMETER SCALE

by Cell&Soft

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Mechano-mimetic cell culture.
Textured rigidity.

In vivo tissues are soft, elastic and mechanically textured. Living tissues rigidity properties present microscale variations that can play a crucial role in cell response (in a same tissue, rigidity varies from Pa/mm to kPa/μm).. Relying on unique patented technologies and know-how derived from the microelectronic field, the mechanical properties of Mecachips® matrices can be finely tuned up to the μm scale to replicate such variations.

DESCRIPTION

MecaChips® soft and micropatterned culture plates are new and physiological solutions for in vitro cell culture, that mimic the mechanical cell environment, all while giving you the chance to control it at the micrometer scale.

APPLICATIONS

AREAS | Basic research, stem cells, oncology, neurology, cardiology.

TOOLS | Adhesion, cell shape standardization, cell confinement, cell migration.

CHARACTERISTICS

BENEFITS | Relevant, robust, reliable, plug & play, compliant, disruptive, scalable to screening workflow (no topography), no biological risk (synthetic matrix), glass bottom: ideal for microscopy, stiffness and coating are decoupled.

STORAGE | Temperature: +4°C. Shelf life: 3 months.

CUSTOMIZATION

1

CHOOSE YOUR PATTERN

Geometrics patterns

Scale: subcellular to cellular

Sizes & shapes*:  

Dots: 0.5 to 10 µm

Triangles: 10 to 100 µm

Stripes : 5 to 100 µm

Scale: tissue

Size: 4.6 mm/ step

Steps

Scale: tissue

Size: Pa/mm to kPa.μm

Gradients

*Custom patterns on request

Culture dishes and plates are pre-coated with ECM protein or synthetic amino acid. Culture dedicated surface chemistry:

2

CHOOSE YOUR COATING

Vitronectin

Human; recombinant truncated

Human; plasma

Fibronectin

Collagen I

Rat; tail

Laminin

Mouse; EHC sarcoma

Poly-Ornithine | Laminin

Poly-Ornithine

One basic format*:

3

CHOOSE YOUR FORMAT

BP35.png

PD35

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*P6 on request

*p384 soon

 

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Polyacrylamide gel with fluorescent beads dispersed inside for Traction Force Microscopy.