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Mechano-mimetic cell culture.
Uniform rigidity.
In vivo, cells lay in soft tissues with distinct physical properties. Rigidity plays a major role in a myriad of cellular mechanisms, such as carcinogenesis and metastasis formation, as well as stem cells differentiation and drug effectiveness. To be representative, in vitro cell devices should selectively provide culture conditions as close as possible to the mechanical microenvironment of targeted tissues.
DESCRIPTION
Cell&Soft culture plates offer mechanical features as close as possible to those found in vivo in animal or human tissues. MecaChips® soft and flat matrices are new and physiological solutions for in vitro cell culture. They mimic the soft mechanical features of all human or animal tissues, thus preserving the cells in vivo characteristics.
APPLICATIONS
AREAS | Basic research, stem cells, oncology, neurology, cardiology, compatible with HCS/HTS platforms.
TOOLS | Cell biology, molecular biology, biochemistry.
CHARACTERISTICS
BENEFITS | Relevant, robust, reliable, plug & play, compliant, disruptive, scalable to screening workflow (no topography), no biological risk (synthetic matrix), glass bottom: ideal for microscopy, stiffness and coating are decoupled, compatible with standard analysis.
STORAGE | Temperature: +4°C. Shelf life: 3 months.
CUSTOMIZATION
1
CHOOSE YOUR STIFFNESS
Stiffness according to the organ of interest:

Breast
1 kPa

Liver
3 kPa

Pancreas
3 kPa

Lung
4 kPa

Artery
5 kPa

Skin
5 kPa

Brain
6 kPa

Spleen
8 kPa

Kidney
9 kPa

Heart
10 kPa

Cartilage >25 kPa
*Specifics stiffnesses on request
Culture dishes and plates are pre-coated with ECM protein or synthetic amino acid. Culture dedicated surface chemistry:
2
CHOOSE YOUR COATING
Vitronectin
Human; recombinant truncated
Human; plasma
Fibronectin
Collagen I
Rat; tail
Laminin
Mouse; EHC sarcoma
Poly-Ornithine | Laminin
Poly-Ornithine
Standards formats*:

PD35

P12

P48

P6

P24

P96
*p384 on request
3
CHOOSE YOUR FORMAT