Mechano-mimetic cell culture.
Textured rigidity.
In vivo tissues are soft, elastic and mechanically textured. Living tissues rigidity properties present microscale variations that can play a crucial role in cell response (in a same tissue, rigidity varies from Pa/mm to kPa/μm).. Relying on unique patented technologies and know-how derived from the microelectronic field, the mechanical properties of Mecachips® matrices can be finely tuned up to the μm scale to replicate such variations.
DESCRIPTION
MecaChips® soft and micropatterned culture plates are new and physiological solutions for in vitro cell culture, that mimic the mechanical cell environment, all while giving you the chance to control it at the micrometer scale.
APPLICATIONS
AREAS | Basic research, stem cells, oncology, neurology, cardiology.
TOOLS | Adhesion, cell shape standardization, cell confinement, cell migration.
CHARACTERISTICS
BENEFITS | Relevant, robust, reliable, plug & play, compliant, disruptive, scalable to screening workflow (no topography), no biological risk (synthetic matrix), glass bottom: ideal for microscopy, stiffness and coating are decoupled.
STORAGE | Temperature: +4°C. Shelf life: 3 months.
CUSTOMIZATION
1
CHOOSE YOUR PATTERN
Geometrics patterns
Scale: subcellular to cellular
Sizes & shapes*:
Dots: 0.5 to 10 µm
Triangles: 10 to 100 µm
Stripes : 5 to 100 µm
Scale: tissue
Size: 4.6 mm/ step
Steps
Scale: tissue
Size: Pa/mm to kPa.μm
Gradients
*Custom patterns on request
Culture dishes and plates are pre-coated with ECM protein or synthetic amino acid. Culture dedicated surface chemistry:
2
CHOOSE YOUR COATING
Vitronectin
Human; recombinant truncated
Human; plasma
Fibronectin
Collagen I
Rat; tail
Laminin
Mouse; EHC sarcoma
Poly-Ornithine | Laminin
Poly-Ornithine
One basic format*:
3
CHOOSE YOUR FORMAT
PD35
*P6 on request
*p384 soon