SOFT CULTURE PLATES,
A NEW GENERATION
OF CELL CULTURE PLATES.
At Cell&Soft, we are comitted to the research and development of soft and biomechanical substrates for in vitro cell culture. Our solutions enhance the physiology and the relevance of cell culture and cell-based assays.
Our team spent years conducting research to develop a new generation of cell culture plates that offers controlled rigidity and mechano-mimetic extracellular environments. Our mission is to reinvent cell culture, by becoming a new and innovative actor for the in vitro research.
WHY CULTURE YOUR CELLS ON SOFT SUBSTRATES?
Because our organs are one billion times softer than plastic.
In vitro cell-based assays are recognized as important contributors to persistent failures to translate promising drug candidates into clinical success, due, in part, to their limited predictability and reproducibility of the in vivo cell models.
In biological conditions, cells organize in tissues with distinct physical properties where they evolve on soft and textured matrices . Matrix rigidities impact almost all aspect of cell behavior . including transcriptional regulation , protein synthesis . endocytosis and even glycolysis necessary for fast metabolism . They play a major role in carcinogenesis and metastasis formation , in stem cells differentiation and in drug effectiveness . Therefore, cell culture devices should not only allow cell survival and growth but must offer an environment as close as possible to the natural microenvironment of targeted tissues to be representative of the in vivo conditions. Up to date, cell-based assays are still performed in plastic dishes, whose rigidity is up to one billion times stiffer than the in vivo cell environment: The failures of standard culture dishes to maintain the phenotype of many primary cells, or by appearing as wrong predictors support the evidence than these standard tools have now reached their limits. Now let’s reinvent cell culture by using soft, mechano-mimetic culture plates!
Mean elastic Young’s moduli of human organs.
WHY USING CELL&SOFT CULTURE PLATES?
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Missirlis D. The effect of substrate elasticity and actomyosin contractility on different forms of endocytosis. PLoS One. 2014 9(5):e96548.
Park JS et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020 578 :621-626
Mouw JK et al. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014 20:360.
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